AMR DetecTool project overview

Global challenge

Antimicrobial resistance (AMR) and healthcare-associated infections (HAI) are among the most severe public health problems, globally and in Europe:

  • limited therapeutic options
  • the mortality rate is increasing
  • long-term impact on the population in reducing the expected life years

AMR has economic burden: increased hospital costs

  • much longer treatment times
  • more tests
  • specialized isolation units
  • stricter hygiene protocols

Our mission: Tackling antimicrobial resistance

Fronts of the fight against antimicrobial resistance:

AMR DetecTool allows to rapid and adequately
  • manage the infected patients
  • improve health outcomes
  • reduce the risk of transmission

Source of the image: Review on Antimicrobial Resistance: https://amr-review.org/infographics.html

We offer rapid diagnostic tools

AMR DetecTool

A rapid and easy-to-use diagnostic system to detecting multidrug-resistant bacteria direct from clinical samples: blood culture, urine, rectal swab, bronchoalveolar lavage / tracheal aspirate.

The current workflow for the detection of the resistance in the microbiological laboratory requires isolation of the bacteria and the application of different methods:

  • disk diffusion
  • Etest
  • combination disk test
  • MALDI-TOF MS

The current technics take between 16-30 hours meaning that the appropriate antibiotic treatment is delayed.

Rapid detection is essential

  • to prevent further spread
  • to fight efficiently against MDR bacteria

This innovation, the AMR DetecTool detects the enzymes directly from the patient’s sample, shortening the workflow for the detection of multidrug-resistant bacteria to 30 min.

Patient & financial benefits

Patient benefits

The AMR DetecTool device can detect the most common resistance mechanisms of bacteria directly from the patient’s sample, enabling the patient to receive the appropriate antibiotic quickly.

The main advantages include:

  • quick and accurate treatments
  • better recovery rate of the patients
  • decrease in mortality
  • shorter hospital stays

Financial benefits

This new, rapid and easy to use diagnostic device helps determine the right antibiotic quickly. The costs associated with prescribing the wrong antibiotic can be avoided. With a quick start to proper treatment, the healing time will be shorter.

AMR DetecTool reduces operational expenses.

The device decreases:

  • treatment costs
  • treatment time
  • length of hospital stay

 

Rapid detection: process & targets

Key features of the AMR DetecTool
  • Concentrates bacteria from liquid sample
  • Eliminates the interferences due to the biological media
  • Improved sensitivity

One device – two functions:

  • Sample processing: filtration – extraction – incubation – deposition
  • AMR detection

Click here to watch a video on using the device

Principle of the detection

LFIA: Lateral Flow ImmunoAssay

The sample is applied at the end of the strip (sample pad), then migrates into the detection zone.

If the target is present in the sample, the antibodies will bind to it, recognising the test line and a control line, and coloured bands will appear.

Rapid AMR tests:
  • ESBL: CTX-M MULTI
  • Carbapenemases: KPC, OXA, VIM, IMP, NDM
  • VAN A/B: vancomycin-resistant Enterococci
  • OXA-Ab: OXA-type carbapenemases in Acinetobacter sp.
  • 3GC: third-generation cephalosporin resistance

Click here for detailed information about the rapid tests

 

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